Sample size calculations for randomised trials including both independent and paired data
نویسندگان
چکیده
منابع مشابه
Sample size calculations in randomised trials: mandatory and mystical.
Investigators should properly calculate sample sizes before the start of their randomised trials and adequately describe the details in their published report. In these a-priori calculations, determining the effect size to detect--eg, event rates in treatment and control groups--reflects inherently subjective clinical judgments. Furthermore, these judgments greatly affect sample size calculatio...
متن کاملSample size calculations for randomized controlled trials.
Most informed consent documents for randomized controlled trials implicitly or explicitly promise the prospective participant that the trial has a reasonable chance of answering a medically important question. The medical literature, however, is replete with descriptions of trials that provided equivocal answers to the questions they addressed. Papers describing the results of such studies may ...
متن کاملErratum to: Sample size calculations for cluster randomised controlled trials with a fixed number of clusters
BACKGROUND Cluster randomised controlled trials (CRCTs) are frequently used in health service evaluation. Assuming an average cluster size, required sample sizes are readily computed for both binary and continuous outcomes, by estimating a design effect or inflation factor. However, where the number of clusters are fixed in advance, but where it is possible to increase the number of individuals...
متن کاملA review of methodology for sample size calculations in cluster randomised trials
Methods A systematic review is being conducted of sample size methodology for cluster randomised trials. The sources for the search include electronic databases PubMed and Web of Science, key text books on cluster randomised trials and discussions with experts in the field. The search strategy involves a compliment of Medical Subject Headings and free text terms to aid a comprehensive search. T...
متن کاملSample size calculations for the ALIGN cluster randomised trial
Justification for the original sample size calculation is made in the trial protocol. In this additional file, we provide details of the assumptions and calculations in estimating the likely width of the 95% confidence interval (CI) for the estimators, the risk difference and the log odds ratio, for the primary practitioner outcome, x-ray referral. Table 1 contains the likely widths of the 95% ...
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ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 2017
ISSN: 0277-6715
DOI: 10.1002/sim.7201